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COX-1, COX-2 Inflammation

There are several COXs (Cyclooxygenases) produced by the body and COX-1 and COX-2 are the most important. COX-1 produces Prostaglandin E1 (PGE1,) which causes pain and inflammation, but also plays a role in protecting the stomach lining. COX-2 produces PGE2, which causes pain and inflammation, but it does not have a role in protecting the stomach lining.

Most NSAIDs (Non Steroidal Anti-Inflammatory Drugs) like Aspirin, Advil, Aleve, etc., inhibit (block) both COX-1 and COX-2 and so, while they relieve pain and inflammation, they can cause varying degrees of gastric ulcerations, perforations or obstructions in one-third to almost one-half of patients taking them.

This is why substances that selectively inhibit COX-2 without interfering with the protective aspects of COX-1 are preferable.

Problem with prescription COX-2 drugs:

Prescription COX-2 inhibitors are bio-chemically engineered substances and have been shown to cause serious cardiovascular effects including heart attacks and death. A recent review published in the journal, Pharmacotherapy concluded that COX-2 inhibitors, like COX-1 inhibitors can cause kidney failure, especially in susceptible individuals.

Why plant-based COX-2 Inhibitors?

Because we need to selectively inhibit COX-2 while preserving the stomach-lining protective function of COX-1. We also need to avoid the serious potential side effects of prescription COX-2 inhibitors. Plant-based COX-2 inhibitors, like those in PreArthos, also have cardiac and gastro-intestinal protective properties. These natural ingredients have no reported adverse effects on kidneys. So, PreArthos and PreArthos + are recommended for effective and safe relief of inflammatory pain and to enhance the use of joints.

 
 
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Pre-disease or early disease is when we have a real opportunity to reduce the burden of chronic disease through evidence-based botanical therapeutic formulations. I believe that this is also the place that many botanical remedies will prove to have the most impact because of their milder, yet optimal therapeutic effects and a almost non-existent side effect profile.

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MD, Director of Education for the Program in Integrative Medicine at the University of Arizona

I’ve recommended PMI’s products with very good results for almost a year now. As people of science, we’re trained to look at evidence and only use therapies that are proven to be effective, and safe

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